Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women: An updated systematic review and meta-analysis of randomized controlled trials

Scientists suggest that soy isoflavones or the combination of and protein may have beneficial effects on inflammation. Thus, present study aims at conducting a systematic review meta-analysis randomized controlled trials (RCTs) in which effect serum concentration C-reactive (CRP) among postmenopausal women is assessed. A literature searching was done to identify breadth related references PubMed, Scopus, ISI Web Science, Cochrane Library, Clinicaltrials.gov up December 2020. The mean change from baseline CRP concentrations its standard deviation (SD) for both intervention comparison groups were used calculate size. summary overall heterogeneity estimated by using DerSimonian Laird random model. protocol registered PROSPERO (No. CRD42020166053). This considered 23 articles 19 meta-analysis. presented non-significant (WMD = 0.08 mg/L, 95 % CI: -0.08, 0.24; p 0.302) indicated levels (WMD= -0.02 mg/L -0.12, 0.08; 0.715). Published RCTs did not provide strong evidence regarding women.